{"id":9984,"date":"2023-05-12T14:37:03","date_gmt":"2023-05-12T12:37:03","guid":{"rendered":"https:\/\/fbhi.se\/cognitive-decline\/"},"modified":"2026-04-18T00:15:05","modified_gmt":"2026-04-17T22:15:05","slug":"kognitiv-svikt","status":"publish","type":"page","link":"https:\/\/fbhi.se\/sv\/kognitiv-svikt\/","title":{"rendered":"Kognitiv svikt"},"content":{"rendered":"[vc_row type=”full_width_background” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” top_padding=”30px” bottom_padding=”30px” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_color=”#3452ff” shape_divider_position=”bottom” shape_divider_height=”40%” bg_image_animation=”none” shape_type=”straight_section” gradient_type=”default”][vc_column column_padding=”padding-2-percent” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”20px” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][vc_row_inner equal_height=”yes” content_placement=”top” column_margin=”none” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”0px” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” font_color=”#006885″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][vc_column_text el_class=”ComboH1+H2″]\n

Demens \u00e4r inte<\/h1>\n[\/vc_column_text][vc_column_text]\n

en del av normalt \u00e5ldrande<\/h2>\n[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner equal_height=”yes” content_placement=”top” column_margin=”60px” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/2″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_column_text]N\u00e4r vi blir \u00e4ldre upplever m\u00e5nga av oss en viss nedg\u00e5ng i n\u00e5gra kognitiva f\u00f6rm\u00e5gor, som minne, snabbhet och probleml\u00f6sningsf\u00f6rm\u00e5ga. Det \u00e4r normalt.<\/span> Demens och kognitiv svikt, d\u00e4remot, orsakas av sjukliga processer som skadar hj\u00e4rncellerna och gradvis bryter ner en persons kognitiva f\u00f6rm\u00e5gor. Vid demens och kognitiv svikt \u00e4r f\u00f6r\u00e4ndringarna tydligare och sker snabbare \u00e4n vid normalt \u00e5ldrande. Symtomen kan vara minnesf\u00f6rlust, sv\u00e5righeter att l\u00f6sa problem och of\u00f6rm\u00e5ga att planera och utf\u00f6ra vardagliga sysslor. Spr\u00e5k, tidsuppfattning och orienteringsf\u00f6rm\u00e5ga p\u00e5verkas negativt. \u00c4ven oro, nedst\u00e4mdhet och beteendef\u00f6r\u00e4ndringar kan tillh\u00f6ra sjukdomsbilden.<\/span><\/p>\n

Orsaker<\/span><\/b><\/h4>\n

Den vanligast f\u00f6rekommande demensformen \u00e4r Alzheimers sjukdom. Sjukdomsutvecklingen f\u00f6rknippas med \u00f6verproduktion och ansamling i hj\u00e4rnan av det kroppsspecifika proteinet beta-amyloid, som klumpar ihop sig och bildar skadligt plack runt hj\u00e4rnans nervceller. I den h\u00e4r processen b\u00f6rjar ett annat protein, tau, ackumuleras och skapa nystan inne i nervcellerna, vilket skadar cellernas funktion. I samband med dessa f\u00f6r\u00e4ndringar uppst\u00e5r inflammation och oxidativ stress, vilket har ytterligare negativ effekt p\u00e5 cellerna.<\/span><\/p>\n

Vid vaskul\u00e4r demens, som \u00e4r den n\u00e4st vanligaste formen, framkallas symtomen av skador och sjukliga f\u00f6r\u00e4ndringar i hj\u00e4rnans blodk\u00e4rl. Hos \u00e4ldre personer \u00e4r det vanligt med blanddemens, vilket inneb\u00e4r att symtomen kan ha olika orsaker, exempelvis b\u00e5de Alzheimers sjukdom och vaskul\u00e4r demens.<\/span><\/p>\n

Genetiska faktorer har betydelse f\u00f6r demensrisken, och risken f\u00f6r Alzheimers sjukdom \u00e4r s\u00e4rskilt f\u00f6rh\u00f6jd f\u00f6r dem som b\u00e4r p\u00e5 genen ApoE4. Dock \u00e4r det s\u00e5 att en person kan ha ApoE4-genen och aldrig utveckla sjukdomen. I FINGER-studien var det tydligt att deltagare med ApoE4 hade stor nytta av studiens livsstilsinterventioner.<\/p>\n

V\u00e5r kognitiva reserv<\/b><\/span><\/h4>\n

V\u00e5ra hj\u00e4rnor \u00e4r formbara och f\u00f6r\u00e4nderliga. I modern neurovetenskap kallar man detta f\u00f6r hj\u00e4rnans plasticitet. Oavsett \u00e5lder kan vi genom kognitiva, fysiska och sociala aktiviteter bygga upp en kognitiv reserv och rikare n\u00e4tverk i hj\u00e4rnan. Om en persons hj\u00e4rna skadas, kan den kognitiva reserven kompensera f\u00f6r skadan, ge lindrigare symtom eller f\u00f6rdr\u00f6ja utvecklingen av symtom. V\u00e5r livsstil, och allt vi g\u00f6r, har betydelse f\u00f6r hj\u00e4rnans funktion, struktur och f\u00f6rm\u00e5ga att anpassa och reparera sig sj\u00e4lv.\u00a0<\/span>[\/vc_column_text][\/vc_column_inner][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/2″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][image_with_animation image_url=”10059″ image_size=”full” animation_type=”entrance” animation=”slide-up” disable_mobile_animation=”true” animation_easing=”easeInOutCubic” animation_movement_type=”transform_y” hover_animation=”none” alignment=”center” border_radius=”20px” box_shadow=”none” image_loading=”skip-lazy-load” max_width=”100%” max_width_mobile=”default”][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row type=”full_width_background” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” top_padding=”0″ bottom_padding=”30px” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_color=”#3452ff” shape_divider_position=”bottom” shape_divider_height=”40%” bg_image_animation=”none” shape_type=”straight_section” gradient_type=”default”][vc_column column_padding=”padding-2-percent” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”20px” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][vc_row_inner equal_height=”yes” content_placement=”top” column_margin=”none” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”0px” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” font_color=”#006885″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][vc_column_text el_class=”ComboH1+H2″]\n

Prevention<\/h1>\n[\/vc_column_text][vc_column_text]\n

och behandling<\/h3>\n[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner equal_height=”yes” content_placement=”top” column_margin=”60px” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/2″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][vc_column_text]\n

Livsstilsinterventioner<\/strong><\/span><\/h4>\n

Den senaste forskningen visar att upp till <\/span>45% av alla fall av demens kan f\u00f6rebyggas eller f\u00f6rdr\u00f6jas med en kombination av multimodala livsstilsinterventioner. Sedan den f\u00f6rsta FINGER-studien publicerades har flera studier genomf\u00f6rts, och m\u00e5nga p\u00e5g\u00e5r eller planeras, f\u00f6r att utveckla FINGER-modellen ytterligare och testa den i olika kulturer, befolkningsgrupper och milj\u00f6er.\u00a0<\/span>
\n<\/span><\/p>\n

L\u00e4kemedel<\/strong><\/span><\/h4>\n

Det finns l\u00e4kemedel som behandlar symtomen, och nu utvecklas ocks\u00e5 sjukdomsmodifierande l\u00e4kemedel som p\u00e5verkar amyloid-ansamlingarna i hj\u00e4rnan och kan bromsa utvecklingen av Alzheimers sjukdom hos vissa patientgrupper.\u00a0<\/span><\/p>\n

Under de kommande \u00e5ren tror vi att precisionspreventiva insatser och l\u00e4kemedelsbehandling kommer att samverka p\u00e5 olika s\u00e4tt och i olika faser, f\u00f6r att motverka demenssjukdom. Inom FINGER-forskningen kombinerar vi just nu livsstilsinterventioner med farmakologiska interventioner f\u00f6r att unders\u00f6ka de f\u00f6rebyggande effekterna.<\/span>[\/vc_column_text][\/vc_column_inner][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/2″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][image_with_animation image_url=”7798″ image_size=”full” animation_type=”entrance” animation=”slide-up” animation_easing=”default” animation_movement_type=”transform_y” hover_animation=”none” alignment=”center” border_radius=”20px” box_shadow=”none” image_loading=”skip-lazy-load” max_width=”100%” max_width_mobile=”default”][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row type=”full_width_background” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” top_padding=”0″ bottom_padding=”30px” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_color=”#3452ff” shape_divider_position=”bottom” shape_divider_height=”40%” bg_image_animation=”none” shape_type=”straight_section” gradient_type=”default”][vc_column column_padding=”padding-2-percent” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”20px” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][vc_row_inner equal_height=”yes” content_placement=”top” column_margin=”none” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”0px” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” font_color=”#006885″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][vc_column_text el_class=”ComboH1+H2″]\n

Antalet demensfall \u00f6kar<\/h1>\n[\/vc_column_text][vc_column_text]\n

i absoluta tal<\/h3>\n[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner equal_height=”yes” content_placement=”top” column_margin=”60px” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/2″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][vc_column_text]Idag \u00e4r den procentuella risken f\u00f6r att utveckla demens l\u00e4gre \u00e4n n\u00e5gonsin i v\u00e4stv\u00e4rlden. Om vi ser till antalet demensfall i befolkningen per tusen inv\u00e5nare \u00e4r det f\u00e4rre personer som f\u00e5r demens, r\u00e4knat i relativa tal. Det anses bland annat bero p\u00e5 h\u00f6gre utbildningsniv\u00e5, b\u00e4ttre kontroll av olika riskfaktorer och en mer h\u00e4lsosam livsstil j\u00e4mf\u00f6rt med tidigare generationer. <\/span><\/p>\n

Eftersom allt fler personer n\u00e5r h\u00f6g \u00e5lder f\u00e5r vi \u00e4nd\u00e5 fler demensfall totalt i samh\u00e4llet, r\u00e4knat i absoluta tal. H\u00f6g \u00e5lder \u00e4r en betydande riskfaktor.<\/span><\/p>\n

I andra delar av v\u00e4rlden, exempelvis i Asien, tycks antalet demensfall \u00f6ka \u00e4ven i relativa tal. Detta kan ha ett samband med \u00f6kad f\u00f6rekomst av riskfaktorer som r\u00f6kning och fetma i dessa regioner. \u00c4ven i v\u00e4stv\u00e4rlden befaras vissa riskfaktorer \u00f6ka och p\u00e5verka n\u00e4sta generations demensrisk, som stress, s\u00f6mnproblem, typ 2-diabetes och nedsatt h\u00f6rsel. Det \u00e4r viktigt att vi i forskningen forts\u00e4tter f\u00f6lja den h\u00e4r\u00a0 utvecklingen och dess effekter.[\/vc_column_text][\/vc_column_inner][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/2″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][image_with_animation image_url=”8051″ image_size=”full” animation_type=”entrance” animation=”slide-up” animation_easing=”default” animation_movement_type=”transform_y” hover_animation=”none” alignment=”center” border_radius=”20px” box_shadow=”none” image_loading=”skip-lazy-load” max_width=”100%” max_width_mobile=”default”][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"

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