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J-MINT (Japan)

J-MINT, the Japan-Multimodal Intervention Trial for Prevention of Dementia, is the first large-scale randomized controlled trial in Japan that examined the efficacy of lifestyle interventions to prevent cognitive decline. The trial, launched in 2019, investigated the preventive effects of multidomain interventions in 531 adults aged 65-85 with mild cognitive impairment and a high risk of developing dementia.

The intervention, comprising physical exercise, nutritional counseling, and cognitive training, was provided for 18 months. Cardiovascular disorders were monitored and treated following Japanese standard guidelines in both intervention and control groups.

The primary outcome of the trial is the change in composite scores of cognitive function. Secondary outcomes include the related changes in physical function, blood biomarkers, brain morphology observed with neuroimaging, and others. Evidence from the trial is expected to inform a large-scale, national implementation of multidomain intervention programs and support further improvements in dementia prevention strategies, medical standards, the medical economy, and societal services.

J-MINT is a multicenter study coordinated by the National Center for Geriatrics and Gerontology (NCGG) with participation from Nagoya University, Nagoya City University, Fujita Health University, and Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology. In parallel, J-MINT PRIME is conducted in Tamba and Kanagawa, aiming at social implementation of multimodal interventions for dementia, engaging 400 participants in less intensive interventions for 18 months. These studies are supported by the Japan Agency for Medical Research and Development.

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