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My-AGELESS (Malaysia)

The Multi-domain Intervention for Reversal of Cognitive Frailty: Towards Personalized Approaches (My-AGELESS Trial) is a randomized controlled trial including 330 seniors at increased risk of cognitive decline and physical frailty, from urban, semi-urban, and rural areas of Malaysia. The main objective of the trial is to evaluate the efficiency, adherence, and cost-efficiency of culture-adapted FINGER lifestyle interventions in Malaysia. The trial also includes sub-studies on gut microbiome.

The intervention group receives a 24-month intervention comprising physical, nutritional, cognitive, and psychosocial aspects, followed by a 12-month period of individual and independent continued intervention. The control group receives regular health monitoring, group counselling sessions, health talks, and advice based on standard public health guidelines.

Primary outcomes include cognitive fragility status, physical function, psychosocial and nutritional status as well a as cognitive performance, vascular health, and gut microbiome. The results will inform personalized rehabilitation medicine in this field, and will be used to develop a telerehabilitation module, intended to help trainers deliver community-based interventions in rural areas. Cost benefits and social impact will be captured for the interest of policy makers.

The My-AGELESS Trial is conducted by the National University of Malaysia under the auspice of the AGELESS Project involving other institution, including University Malaya, University Technology Mara, University Putra Malaysia, and Monash University of Malaysia, supported by the Ministry of Education of Malaysia Longterm Research Grant Scheme.